Having studied Architecture and Civil Engineering at the University of Malta, Jeanette went on to read for a Masters and PhD in Structural Engineering at Imperial College London. At the same institution, Jeanette also held a Post-Doctoral position and gained teaching experience working with both undergraduate and postgraduate students.

Over the years, Jeanette has worked on numerous projects in various roles in both the UK and Malta. Her projects varied from stadium roofs (London Olympics main stadium legacy period, UK) to bridge design (Osman Ghazi Bridge, Turkey), medium-rise towers (Tipico Building, Malta) and hotels (Dolmen and Hilton Hotels. Malta), museums (Gozo Museum, Malta) and various residential projects. Jeanette is founding director of Bureau 105, where she focuses on the design of human-centred sustainable projects, involving community participatory design and structurally optimised solutions. She is also a co-host of 'The Human Agenda' podcast targeted at increasing sustainability and regenerative design processes and thoughts of the general public.

Moreover, Jeanette is also active in research and lecturing at the University of Malta within the Faculty for the Built Environment. Her areas of interest are instability of structures, topology optimisation of structures, and the interdisciplinary approach in the fusion of architecture and engineering by way of enhancing the experience and well-being of the ultimate user of the project. As part of her university commitment, Jeanette also sits on the University Senate (2019-2021), the Faculty Board (2019 – to date) and the Doctoral Committee (2019 – to date).

She is a council member of the Kamra tal-Periti (KTP) since 2016 where she acts as representative on the European Council of Civil Engineers (ECCE), Fédération Européenne d'Associations Nationales d'Ingénieurs (FEANI) and Inġiniera Malta in their General Assemblies as well as a member of the union Internationale des Architects (UIA) Committee "International Women in Architecture". Jeanette is also the Chair of the Permanent Committee on Engineering (Malta) and national representative of the International Association of Bridge and Structural Engineering (IABSE).